About FENTORA

Frequently Asked Questions about FENTORA

Get answers to frequently asked questions about FENTORA:

Q: What is FENTORA?

A: FENTORA is used to treat breakthrough pain in adult patients with cancer (18 years of age and older) who are regularly using other opioid pain medicines around the clock for their constant cancer pain.

FENTORA is a prescription medicine that contains the medicine fentanyl. FENTORA is a federally controlled substance (C-II) because it is a strong opioid pain medicine that can be abused by people who abuse medicines or street drugs. Read more.

The Risk Minimization Action Plan for FENTORA is designed to promote safe and appropriate use of the product. Read more.

Q: How does FENTORA work?

A: FENTORA uses OraVescent® Technology to quickly distribute medicine to your body and give you relief. The tablet should be placed above a rear molar tooth between your cheek and gum, as it’s not meant to be chewed or swallowed. You may feel a gentle bubbling sensation between your cheek and gum as the tablet dissolves.

Some patients may start to feel relief as early as 15 minutes. Learn more.

Q:How is FENTORA different from the medicine I already take for my persistent pain?

A: The medicine you already take daily for your persistent pain is an around-the-clock opioid pain medicine that works throughout the day.

FENTORA is a treatment for breakthrough cancer pain (an intense flare or spike that rises above persistent pain). You must continue to use your around-the-clock opioid medicine while you are using FENTORA. Learn more.

Q: Is FENTORA right for me?

A: That’s only something you and your healthcare professional can decide. FENTORA is used to treat breakthrough pain in adults, 18 years of age and older with cancer, who are regularly using other opioid pain medicines around the clock for their constant cancer pain. FENTORA is started only after you have been taking other opioid pain medicines and your body has gotten used to them (you are opioid tolerant). DO NOT USE FENTORA if you are not opioid tolerant.

Do Not Take FENTORA:

  • if you are not regularly using other opioid pain medicines around the clock for your constant cancer pain
  • for the treatment of short-term pain from injuries, surgery, and headaches, including migraines
  • if you are allergic to anything in FENTORA. The active ingredient is fentanyl. See the Medication Guide for a complete list of ingredients in FENTORA

Q: Does FENTORA have a taste?

A: FENTORA contains no added flavors. You may sense a slight taste, or you may notice nothing at all.

Q: Is there sugar in FENTORA?

A: No. FENTORA is sugar free.

Q: How is FENTORA packaged?

A: FENTORA comes in individually sealed child-resistant blister packs. Once removed from the blister pack, a FENTORA tablet must be taken immediately.

Q: How do I take FENTORA?

A: Follow these 3 easy steps:

1. Peel from blister card. 2. Place it in your mouth. 3. Feel it dissolve and work quickly.

Read more about how to properly take FENTORA.

Q: When do I take FENTORA?

A: Once your healthcare professional has determined FENTORA is the right treatment for you, you should take FENTORA as soon as you start to feel a flare of breakthrough cancer pain. Read more.

Q: How does my healthcare professional find the right dose of FENTORA to relieve my breakthrough cancer pain?

A: To start you on FENTORA, your healthcare professional will likely prescribe a low-dosage strength. Read more.

Your healthcare professional may gradually increase the dosage strength of FENTORA to find the right dose for you. To help with this process, your healthcare professional may instruct you to use several tablets at the same time. Read more.

By following your healthcare professional's instructions during this adjustment period, and telling the healthcare professional how you’re feeling, you can help your healthcare professional determine a correct dose. A daily pain journal can be a useful tool for remembering your experiences and talking with your healthcare professional about them. Ask your healthcare professional for details.

Once your healthcare professional finds the dose of FENTORA that is right for you, you should use only 1 FENTORA tablet per breakthrough pain flare. Read more.

Q: When can I expect FENTORA to work?

A: Some people may start to feel relief as early as 15 minutes. If a flare or episode of breakthrough cancer pain is not relieved within 30 minutes, your healthcare professional may instruct you to take ONLY 1 additional dose. (Do not take more than 2 doses.) You must wait at least 4 more hours before taking FENTORA for another flare of breakthrough cancer pain. See the special instructions for taking an additional dose in the Medication Guide.

Q: What if I still have breakthrough cancer pain after taking a single dose of FENTORA?

A: On some occasions, a single dose of FENTORA may not control your breakthrough cancer pain because some flares of pain may be more severe. If your pain is not relieved within 30 minutes, your healthcare professional may instruct you to take ONLY 1 additional dose. (Do not take more than 2 doses.) You must wait at least 4 more hours before taking FENTORA for another flare of breakthrough pain. Read more.

Q: Can I bite, chew, suck, or swallow FENTORA?

A: No. Do not bite, chew, or suck on a FENTORA tablet. Do not swallow tablets whole. If you do so, you will swallow more of the medicine before it can cross the lining of your mouth, and you may get less relief for your breakthrough cancer pain. Read more about taking FENTORA.

Q: Can I take FENTORA if I have a dry mouth?

A: Yes. If you have difficulty producing saliva, please talk with your healthcare professional. You may drink some water before taking FENTORA, but you should not eat or drink anything while taking FENTORA. Read more about taking FENTORA.

Q: While taking FENTORA, do I still take my around-the-clock opioid pain medicine?

A: You must continue to take your around-the-clock opioid pain medicine as long as you are taking FENTORA. Do not stop taking your around-the-clock opioid pain medicine. Talk with your healthcare professional before making an adjustment to any of your other medicines.

Always discuss any questions about your medicine with your healthcare professional. Read more about taking FENTORA.

Q: What do I do if I am currently on Actiq®?

A: When starting FENTORA, discontinue use of Actiq®/OTFC (oral transmucosal fentanyl citrate). Dispose of all remaining units properly.

Your healthcare professional will prescribe a starting dose of FENTORA that is different from other fentanyl containing medicines you may have been taking. Do not substitute FENTORA for other fentanyl medicines, including Actiq®, without talking with your healthcare professional.

Q: What are the possible or likely side effects of FENTORA?

A: All medicines have benefits and risks. The most common side effects of FENTORA are nausea, vomiting, dizziness, sleepiness, headache, and constipation. These are not all the possible side effects of FENTORA. For a complete list, ask your healthcare professional.

Constipation (not often enough or hard bowel movements) is a very common side effect of opioid pain medicines and may happen with FENTORA. Constipation is unlikely to go away without treatment. Talk with your healthcare professional about changes in your diet and the use of laxatives and stool softeners to prevent or treat constipation while taking FENTORA.

Call your healthcare professional for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Read more about potentially serious side effects.

Q: When should I call emergency help?

A: FENTORA can cause serious breathing problems, including slow, shallow breathing that can become life threatening, especially if FENTORA is used the wrong way.

Call your healthcare professional, or get emergency medical help right away, if you or the person taking the medication is:

  • Having trouble breathing
  • Having extreme drowsiness, with slowed breathing
  • Having slow, shallow breathing (little chest movement while breathing)
  • Feeling faint, very dizzy, confused, or have unusual symptoms

The above symptoms may lead to serious problems or death if not treated right away. Read more about potentially serious side effects.

Q: What should I tell my healthcare professional before starting FENTORA?

A: Tell your healthcare professional about all medical and mental health issues, especially if you or the person you’re caring for has:

  • Trouble breathing or lung problems such as asthma, wheezing, or shortness of breath
  • A head injury or brain problem
  • Liver or kidney problems
  • Seizures (convulsions or fits)
  • Slow heart rate or other heart problems
  • Low blood pressure
  • Mental health issues including major depression or hallucinating (seeing or hearing things that are not there)
  • A past or present drinking problem or alcoholism, or family history
  • A past or present drug abuse or addiction problem, or family history

Tell your healthcare professional if you or the person you’re caring for is:

  • Pregnant or planning to become pregnant. FENTORA may harm your unborn baby
  • Breast-feeding. Fentanyl passes through breast milk and may cause serious harm to your baby. Therefore, you should not use FENTORA while breast-feeding

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal and dietary supplements.

Read more about using FENTORA safely.

Q: Can I use medicines (other than my pain medicine) and herbal products while taking FENTORA?

A: Do not start any new prescription medicine, non-prescription medicine, vitamins, or herbal supplements while using FENTORA until you have talked with your healthcare professional. Your healthcare professional will tell you if it is safe to take other medicines while you are using FENTORA. Read more about taking FENTORA safely.

Q: Can I drink alcoholic beverages while taking FENTORA?

A: Do not drink alcohol while using FENTORA. Drinking alcohol can produce dangerous side effects, resulting in serious injury or death. Read more about taking FENTORA safely.

Q: Who should not take FENTORA?

A: You should not take FENTORA if you:

  • Are not regularly using other opioid pain medicines for your persistent cancer pain
  • Only have short-term pain from injuries, surgery, and headaches, including migraines
  • Are allergic to anything in FENTORA. The active ingredient in FENTORA is fentanyl. The other ingredients are mannitol, sodium starch glycolate, sodium bicarbonate, sodium carbonate, citric acid, and magnesium stearate

Read more about taking FENTORA safely.

Q: How should I store FENTORA?

A: Keep FENTORA in a safe and secure place away from children and anyone for whom it has not been prescribed. Accidental use by a child is a medical emergency and can result in death. If a child accidentally takes FENTORA, get emergency help right away.

FENTORA is supplied in single sealed, child-resistant blister packages. Keep tablets in their blister packages until you are ready to take FENTORA. Do not store FENTORA in pillboxes. Once a blister is opened, the tablet must be taken immediately.

Store FENTORA at room temperature, 59°F to 86°F (15°C-30°C), until ready to use.

Always keep FENTORA in a secure place to protect from theft.

Read more about properly storing FENTORA.

Q: How should I dispose of unopened FENTORA tablets when they are no longer needed?

A: Dispose of any unopened FENTORA tablets remaining from a prescription as soon as they are no longer needed.

To dispose of unused FENTORA, remove FENTORA tablets from blister packages and flush down the toilet. Do not flush the FENTORA blister packages or cartons down the toilet.

If you need help with disposal of FENTORA, or information on how to return unused tablets, call Cephalon at 1-800-896-5855.

Read more about how to properly dispose of FENTORA.

Q: What happens if someone accidentally swallows my FENTORA?

A: Life-threatening respiratory depression could occur at any dose in opioid non-tolerant patients. Call 911 or emergency help immediately.

Q: What is addiction?

A: Addiction is a chronic disease that is characterized by one or more of the following: impaired control over drug use, compulsive use, continued use despite harm, and craving of a medicine. Read more about using FENTORA safely.

Q: Are opioid pain medicines addictive?

A: When taken under a healthcare professional’s supervision, FENTORA can be a safe and effective pain-management tool. However, there is a chance you could get addicted to opioid pain medication including FENTORA. The chance is higher if you are or were ever addicted to other medicines, street drugs, or alcohol, or if you abused them. The chance is also higher if you have a history of mental health issues. Talk with your healthcare professional about the risk of addiction.

Q: Will my insurance or Medicaid cover the cost of FENTORA?

A: FENTORA is eligible for Medicaid reimbursement in all 50 states; however, coverage may vary from state to state.

If you have questions about whether FENTORA is covered under your insurance plan, you can call the FENTORA Reimbursement Program toll-free at 1-877-4FENTORA (1-877-433-6867). Reimbursement specialists can answer your questions about insurance coverage, reimbursement, and limitations. They can help you and your physician with pre-authorizations and denied claims.

Cephalon does not formally conduct appeals for callers. The responsibility for obtaining prior authorization and seeking appeals ultimately must rest with patients and providers.

Read more about the different ways you can pay for FENTORA.

Q: What if I don't have insurance?

A: For patients with no prescription drug coverage, or limited financial resources, the CephalonCares® Foundation can help patients get the Cephalon medicines they need. For more information, call 1-877-CEPH-881 (1-877-237-4881) or visit CephalonCares.com.

Read more about patient-assistance programs.

IMPORTANT:

Do not use FENTORA unless you are regularly using another opioid pain medicine around-the-clock for your cancer pain and your body is used to these medicines (this means you are opioid tolerant). You can ask your healthcare provider if you are opioid tolerant.

Keep FENTORA in a safe place away from children.

Get emergency help right away if:

  • a child takes FENTORA. FENTORA can cause an overdose and death in any child who takes it.
  • an adult who has not been prescribed FENTORA uses it
  • an adult who is not already taking opioids around-the-clock, uses FENTORA.

These are medical emergencies that can cause death. If possible, try to remove FENTORA from the mouth.

Read this Medication Guide completely before you start using FENTORA, and each time you get a new prescription. There may be new information. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or your treatment. Share this important information with members of your household and other caregivers.

FENTORA is used to treat breakthrough pain in adult patients with cancer (18 years of age and older) who are regularly using other opioid pain medicines around-the-clock for their constant cancer pain.

The most important information you should know about FENTORA is:

FENTORA can cause life-threatening breathing problems which can lead to death.

  1. Do not use FENTORA if you are not opioid tolerant.
  2. If you stop taking your around-the-clock opioid pain medicine for your cancer pain, you must stop using FENTORA. You may no longer be opioid tolerant. Talk to your healthcare provider about how to treat your pain.
  3. Use FENTORA exactly as prescribed by your healthcare provider.
    • You must not use more than 2 doses of FENTORA for each episode of breakthrough cancer pain.
    • You must wait at least 4 hours before treating a new episode of breakthrough pain with FENTORA. See the Medication Guide section “How should I use FENTORA?” and the Patient Instructions for Use at the end of this Medication Guide for detailed information about how to use FENTORA the right way.
  4. Do not switch from FENTORA to other medicines that contain fentanyl without talking with your healthcare provider. The amount of fentanyl in a dose of FENTORA is not the same as the amount of fentanyl in other medicines that contain fentanyl. Your healthcare provider will prescribe a starting dose of FENTORA that may be different than other fentanyl containing medicines you may have been taking.